Sperm DNA Fragmentation

530.00 zł

“DIAGNOSTIC TEST PANEL FOR MEN” sample collection kit is designed for the secure transportation of material for the sperm DNA fragmentation test to the INVICTA Medical Diagnostic Laboratories. Sperm DNA fragmentation test allows to analyze the quality of the genetic material as a prognostic parameter of the efficacy rate for fertilization, pregnancy development and giving birth to a healthy baby.

INDICATIONS

  • Diagnosis of male infertility
  • Infertility treatment failures
  • Habitual abortions
  • Before starting the IVF program or undergoing insemination
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Description

DIAGNOSTIC TEST PANEL FOR MEN” sample collection kit is designed for the secure transportation of material for the sperm DNA fragmentation test to the INVICTA Medical Diagnostic Laboratories. Sperm DNA fragmentation test allows to analyze the quality of the genetic material as a prognostic parameter of the efficacy rate for fertilization, pregnancy development and giving birth to a healthy baby.

Sperm DNA fragmentation

Sperm DNA fragmentation test allows for detailed examination of the quality of the genetic material as a prognostic parameter of the efficacy rate for fertilization, pregnancy development and giving birth to a healthy baby. A standard sperm test does not always provide all necessary information that could be used to determine the patient’s fertility.

Embryos obtained as a result of fertilization of an egg cell with a sperm with an abnormal (high) rate of DNA fragmentation are related to a poorer prognosis as early as at the stage of a blastocyst (a 5-day embryo). When delivered to the uterus, they attach significantly more poorly, and pregnancies started with such embryos may result in miscarriages, abnormalities and increased susceptibility of offspring to cancer developing. In case of continued high level of sperm DNA fragmentation it is recommended to carry out the in vitro fertilization procedure with specialized preimplantation diagnosis (PGS/PGD NGS). It allows to reduce the risk of genetic diseases or defects in the couple’s child.

An increased rate of sperm DNA fragmentation is associated, among others, with infections, fever, elevated temperature of the testicular area, cigarette smoking, inappropriate diet, substance abuse, exposure to environmental contamination, as well as the advanced age. Treatment, or more precisely reducing the fragmentation rate, depends on a causative factor. If chromatin damage has been caused by oxidative stress, a change in the lifestyle and a well-balanced diet may improve the DNA damage rate. In case of infections, the use of antibiotic therapy may also improve the fragmentation rate. The efficacy of activities undertaken has to be checked and the genetic material has to be assessed again, 2-3 months after the first analysis.

Additional information

PREPARATION

The semen collection should be performed after 2 -7 days of sexual continence. Semen is obtained by masturbation.

CONTENTS OF THE SET

Sterile container for semen collection – 1 pc, Test tube with preservative for semen (test tube with yellow-red stopper) – 1 pc, A set of bar codes (test code identification) – 1 pair, Cooling inserts – 2 pcs, Referral for sperm DNA fragmentation test -1 pc

TEST METHOD

TUNEL

TIME TO RESULTS

10 days

REFERRAL FOR TESTING

Data to be entered on the referral: first name, surname, PESEL [Personal Number], date of birth, address for sending the test report (results), date and hour of material collection, clinical diagnosis / indication to test performance, type of material, ordered test/s, patient’s signature, signed informed consent for genetic testing.

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