DIAGNOSTIC TEST PANEL FOR MEN” sample collection kit is designed for the secure transportation of material for the sperm DNA fragmentation test to the INVICTA Medical Diagnostic Laboratories. Sperm DNA fragmentation test allows to analyze the quality of the genetic material as a prognostic parameter of the efficacy rate for fertilization, pregnancy development and giving birth to a healthy baby.
Sperm DNA fragmentation
Sperm DNA fragmentation test allows for detailed examination of the quality of the genetic material as a prognostic parameter of the efficacy rate for fertilization, pregnancy development and giving birth to a healthy baby. A standard sperm test does not always provide all necessary information that could be used to determine the patient’s fertility.
Embryos obtained as a result of fertilization of an egg cell with a sperm with an abnormal (high) rate of DNA fragmentation are related to a poorer prognosis as early as at the stage of a blastocyst (a 5-day embryo). When delivered to the uterus, they attach significantly more poorly, and pregnancies started with such embryos may result in miscarriages, abnormalities and increased susceptibility of offspring to cancer developing. In case of continued high level of sperm DNA fragmentation it is recommended to carry out the in vitro fertilization procedure with specialized preimplantation diagnosis (PGS/PGD NGS). It allows to reduce the risk of genetic diseases or defects in the couple’s child.
An increased rate of sperm DNA fragmentation is associated, among others, with infections, fever, elevated temperature of the testicular area, cigarette smoking, inappropriate diet, substance abuse, exposure to environmental contamination, as well as the advanced age. Treatment, or more precisely reducing the fragmentation rate, depends on a causative factor. If chromatin damage has been caused by oxidative stress, a change in the lifestyle and a well-balanced diet may improve the DNA damage rate. In case of infections, the use of antibiotic therapy may also improve the fragmentation rate. The efficacy of activities undertaken has to be checked and the genetic material has to be assessed again, 2-3 months after the first analysis.